AUTHOR=Guo Yeting , Ying Jianxi , Sun Dongru , Zhang Yumeng , Zheng Minyang , Ding Ruiwen , Liu Yan , Zhao Yufen TITLE=Cyclic Dipeptides Formation From Linear Dipeptides Under Potentially Prebiotic Earth Conditions JOURNAL=Frontiers in Chemistry VOLUME=9 YEAR=2021 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.675821 DOI=10.3389/fchem.2021.675821 ISSN=2296-2646 ABSTRACT=

Cyclic dipeptides (DKPs) are peptide precursors and chiral catalysts in the prebiotic process. This study reports proline-containing DKPs that were spontaneously obtained from linear dipeptides under an aqueous solution. Significantly, the yields of DKPs were affected by the sequence of linear dipeptides and whether the reaction contains trimetaphosphate. These findings provide the possibility that DKPs might play a key role in the origin of life.