AUTHOR=Wan Junlin , Jiang Jun , Li Juan 

TITLE=Chiral Phosphoric Acid Promoted Chiral 1H NMR Analysis of Atropisomeric Quinolines

JOURNAL=Frontiers in Chemistry

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.672704

DOI=10.3389/fchem.2021.672704

ISSN=2296-2646

ABSTRACT=<p>An efficient enantioselective NMR analysis of atropisomeric quinolines in the promotion of chiral phosphoric acid is described, in which a variety of racemic 4-aryl quinolines were well-recognized with up to 0.17 ppm ΔΔδ value. Additionally, the optical purities of different nonracemic substrates could be evaluated fast via NMR analysis with high accuracy.</p>