AUTHOR=Ding Rongcai , Li Yingxue , Chang Yaoyao , Liu Yue , Yu Jie , Lv Yanna , Hu Jinxing 

TITLE=Metal-Free Direct C–H Functionalization of Quinoxalin-2(1H)-Ones to Produce 3-Vinylated Quinoxalin-2(1H)-Ones in the Presence of Alkenes

JOURNAL=Frontiers in Chemistry

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.672051

DOI=10.3389/fchem.2021.672051

ISSN=2296-2646

ABSTRACT=<p>A novel and efficient <italic>C</italic><sub>3</sub>-<italic>H</italic> vinylation reaction with quinoxalin-2(1<italic>H</italic>)-one as the substrate, in the presence of alkenes, under metal-free conditions, is reported herein. The reaction leads to the formation of new carbon–carbon bonds that exhibit moderate to good reactivities. The vinylation of quinoxalin-2(1<italic>H</italic>)-ones, in the presence of alkenes, is an attractive process that can be potentially utilized to produce biologically active 3-vinylated quinoxalin-2(1<italic>H</italic>)-ones.</p>