AUTHOR=Liu Zhenhua , Niu Yun , Zhou Li , Meng Lijun , Chen Sitan , Wang Mengke , Hu Jiangmiao , Kang Wenyi 

TITLE=Nine Unique Iridoids and Iridoid Glycosides From Patrinia scabiosaefolia

JOURNAL=Frontiers in Chemistry

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.657028

DOI=10.3389/fchem.2021.657028

ISSN=2296-2646

ABSTRACT=<p><italic>Patrinia scabiosaefolia</italic> is a medical and edible Chinese herb with high nutritional and medicinal value. The continuing study of its chemical constituents led to the discovery of nine unique iridoids and iridoid glycosides, including three new iridoids (<bold>1</bold>-<bold>3</bold>) and six previously unknown irioid glycosides (<bold>5</bold>-<bold>10</bold>), and one known compound (<bold>4</bold>). Among them, compound <bold>1</bold> was a deformed iridoid, while compounds <bold>3</bold>, <bold>5</bold>-<bold>7</bold>, and <bold>10</bold> formed a new ring in their skeletons which was uncommon in this genus. For compound <bold>3</bold>, the new ring existed between C-3 and C-10, while a 1,3-dioxane appeared between C-7 and C-10 in compounds <bold>5</bold>-<bold>7</bold> and <bold>10</bold>. Moreover, compound <bold>10</bold> was a bis-iridoid glycoside, which was the first reported in <italic>P</italic>. <italic>scabiosaefolia</italic>. And the sugar of irioid glycosides (<bold>5</bold>-<bold>10</bold>) was glucose at C-11, except in <bold>9</bold> which had a 5-deoxyglucose moiety. All their structures were confirmed based on the extensive spectroscopic analysis, including IR, UV, HR-ESI-MS, ECD, and 1D- and 2D-NMR experiments. Their cytotoxic activities against HL-60, A-549, SMMC-7721, MCF-7, SW480 were also tested.</p>