AUTHOR=Prabhu C. P. Keshavananda , Nemakal Manjunatha , Managa Muthumuni , Nyokong Tebello , Koodlur Sannegowda Lokesh TITLE=Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application JOURNAL=Frontiers in Chemistry VOLUME=9 YEAR=2021 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.647331 DOI=10.3389/fchem.2021.647331 ISSN=2296-2646 ABSTRACT=

N4 macrocyclic complexes of Al and Zn phthalocyanines with symmetrical imine and imidazole moiety at the periphery were synthesized. The synthesized ligands, complexes, and polymers were purified and characterized to study the structure of the molecule. These synthesized complexes were used for photodynamic therapy application as the diamagnetic Zn and Al have the ability to produce and stabilize singlet oxygen species. The synthesized N4 molecules of aluminum iminomethoxy phenyl phthalocyanine and aluminum ethyl phenyl benzimidazolephthalocyanine showed better activity against MCF-7 cells. These results suggest that this assay may be used as an early biomarker of clinical response.