AUTHOR=Tian Ye , Chong Xiao-Meng , Liu Ying , Han Ying , Hu Chang-Qin , Yao Shang-chen , Xu Ming-Zhe TITLE=Study on Isomeric Impurities in Cefotiam Hydrochloride JOURNAL=Frontiers in Chemistry VOLUME=8 YEAR=2021 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2020.619307 DOI=10.3389/fchem.2020.619307 ISSN=2296-2646 ABSTRACT=

In this study, two isomeric impurities were identified in cefotiam hydrochloride injection preparation and were characterized. Column-switching HPLC-MS and NMR techniques were used to identify the impurity 1 as the Δ3(4) isomers of cefotiam. Using software-based calculations, it was predicted that neither of the isomeric impurities was embryotoxic. This study provides a reference for the production, storage, and quality control of cefotiam and related cephalosporin antibiotics.