AUTHOR=Ma Hongshi , Ma Zhenjiang , Chen Qufei , Li Wentao , Liu Xiangfei , Ma Xiaojun , Mao Yuanqing , Yang Han , Ma Hui , Wang Jinwu TITLE=Bifunctional, Copper-Doped, Mesoporous Silica Nanosphere-Modified, Bioceramic Scaffolds for Bone Tumor Therapy JOURNAL=Frontiers in Chemistry VOLUME=8 YEAR=2020 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2020.610232 DOI=10.3389/fchem.2020.610232 ISSN=2296-2646 ABSTRACT=
In the traditional surgical intervention procedure, residual tumor cells may potentially cause tumor recurrence. In addition, large bone defects caused by surgery are difficult to self-repair. Thus, it is necessary to design a bioactive scaffold that can not only kill residual tumor cells but also promote bone defect regeneration simultaneously. Here, we successfully developed Cu-containing mesoporous silica nanosphere-modified β-tricalcium phosphate (Cu-MSN-TCP) scaffolds, with uniform and dense nanolayers with spherical morphology