AUTHOR=Qu Jianbo , Zhang Zhi-Hao , Zhang Haitao , Weng Zhen-Tao , Wang Jian-Yong 

TITLE=Diethyl Malonate-Based Turn-On Chemical Probe for Detecting Hydrazine and Its Bio-Imaging and Environmental Applications With Large Stokes Shift

JOURNAL=Frontiers in Chemistry

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2020.602125

DOI=10.3389/fchem.2020.602125

ISSN=2296-2646

ABSTRACT=<p>Diethyl malonate-based fluorescent probe <bold>NE-N</bold><sub><bold>2</bold></sub><bold>H</bold><sub><bold>4</bold></sub> was constructed for monitoring hydrazine (N<sub>2</sub>H<sub>4</sub>). The novel probe <bold>NE-N</bold><sub><bold>2</bold></sub><bold>H</bold><sub><bold>4</bold></sub> exhibits good properties, such as large Stokes shift (about 125 nm), good selectivity, and low cytotoxicity. This sensing probe <bold>NE-N</bold><sub><bold>2</bold></sub><bold>H</bold><sub><bold>4</bold></sub> can be operated to detect hydrazine in living HeLa cells. Especially after soaking in probe solution, the thin-layer chromatography (TLC) plate could detect the vapor of hydrazine. Therefore, the probe <bold>NE-N</bold><sub><bold>2</bold></sub><bold>H</bold><sub><bold>4</bold></sub> might be used to monitor hydrazine in biosamples and environmental problem.</p>