AUTHOR=Ma Ya , Canup Brandon S. B. , Tong Xiaoling , Dai Fangyin , Xiao Bo 

TITLE=Multi-Responsive Silk Fibroin-Based Nanoparticles for Drug Delivery

JOURNAL=Frontiers in Chemistry

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2020.585077

DOI=10.3389/fchem.2020.585077

ISSN=2296-2646

ABSTRACT=<p>Silk fibroin has the merits of biocompatibility, biodegradability, ease of processing, and feasibility of modification, which present it as a promising drug delivery material. This review focuses on the structures of silk fibroin, the controlled transformation of secondary structures, and the formation mechanism of silk fibroin-based nanoparticles (SFNPs). We also discuss the intrinsic multi-responsive, surface functionalization, and transgenic modification of SFNPs for drug delivery.</p>