AUTHOR=Liu Jianhua , Kotrchová Lenka , Lécuyer Thomas , Corvis Yohann , Seguin Johanne , Mignet Nathalie , Etrych Tomáš , Scherman Daniel , Randárová Eva , Richard Cyrille 

TITLE=Coating Persistent Luminescence Nanoparticles With Hydrophilic Polymers for in vivo Imaging

JOURNAL=Frontiers in Chemistry

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2020.584114

DOI=10.3389/fchem.2020.584114

ISSN=2296-2646

ABSTRACT=<p>Persistent luminescence nanoparticles (PLNPs) are innovative nanomaterials highly useful for bioimaging applications. Indeed, due to their particular optical properties, i.e., the ability to store the excitation energy before slowly releasing it for a prolonged period of time, they allow <italic>in vivo</italic> imaging without auto-fluorescence and with a high target to background ratio. However, as for most nanoparticles (NPs), without any special surface coating, they are rapidly opsonized and captured by the liver after systemic injection into small animals. To overcome this issue and prolong nanoparticle circulation in the bloodstream, a new stealth strategy was developed by covering their surface with poly(<italic>N</italic>-2-hydroxypropyl)methacrylamide (pHPMA), a highly hydrophilic polymer widely used in nanomedicine. Preliminary <italic>in vivo</italic> imaging results demonstrated the possibility of pHPMA as an alternative strategy to cover ZnGa<sub>2</sub>O<sub>4</sub>:Cr NPs to delay their capture by the liver, thereby providing a new perspective for the formulation of stealth NPs.</p>