AUTHOR=Somo Sami I. , Brown Jacob M. , Brey Eric M. TITLE=Dual Crosslinking of Alginate Outer Layer Increases Stability of Encapsulation System JOURNAL=Frontiers in Chemistry VOLUME=8 YEAR=2020 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2020.575278 DOI=10.3389/fchem.2020.575278 ISSN=2296-2646 ABSTRACT=
The current standard treatment for Type 1 diabetes is the administration of exogenous insulin to manage blood glucose levels. Cellular therapies are in development to address this dependency and allow patients to produce their own insulin. Studies have shown that viable, functional allogenic islets can be encapsulated inside alginate-based materials as a potential treatment for Type 1 diabetes. The capability of these grafts is limited by several factors, among which is the stability and longevity of the encapsulating material