AUTHOR=Arif Dooa , Hussain Zakir , Sohail Manzar , Liaqat Muhammad Arman , Khan Muzamil Ahmad , Noor Tayyaba 

TITLE=A Non-enzymatic Electrochemical Sensor for Glucose Detection Based on Ag@TiO2@ Metal-Organic Framework (ZIF-67) Nanocomposite

JOURNAL=Frontiers in Chemistry

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2020.573510

DOI=10.3389/fchem.2020.573510

ISSN=2296-2646

ABSTRACT=<p>This work presents the preparation of an efficient and sensitive glucose sensor for the detection of glucose in an alkaline media. The glucose sensor is composed of a metal organic framework (MOF) composite comprising Ag@TiO<sub>2</sub> nanoparticles. The hybrid of Ag@TiO<sub>2</sub> encapsulated in ZIF-67 was synthesized by the solvothermal method and applied onto a glassy carbon electrode (GCE) for the non-enzymatic sensing of glucose. The porosity of ZIF-67 was favorable for the unhindered diffusion and entrapment of glucose and its cavities served as reaction vessels. The electrochemical behavior of Ag@TiO<sub>2</sub>@ZIF-67 showed amplified results when compared with that of Ag@TiO<sub>2</sub> and ZIF-67. Cyclic tests toward the oxidation of glucose has demonstrated excellent stability of a MOF-based hybrid sensor. The sensor based on Ag@TiO<sub>2</sub>@ZIF-67 showed high sensitivity of 0.788 μAμM<sup>−1</sup>cm<sup>−2</sup> with a linear concentration range of 48 μM<sup>−1</sup> mM and a response time of 5 s with an excellent detection limit of 0.99 μM (S/N = 3).</p>