AUTHOR=Nao Sang-Cuo , Wu Ke-Jia , Wang Wanhe , Leung Chung-Hang , Ma Dik-Lung 

TITLE=Recent Progress and Development of G-Quadruplex-Based Luminescent Assays for Ochratoxin A Detection

JOURNAL=Frontiers in Chemistry

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2020.00767

DOI=10.3389/fchem.2020.00767

ISSN=2296-2646

ABSTRACT=<p>Ochratoxin A (OTA) is a mycotoxin that is widespread throughout the world. It contaminates foods such as vegetables, fruits, and rice. It harms human health and has potential carcinogenic effects. The G-quadruplex (G4) is a tetraplexed DNA structure generated from guanine-rich DNA that has found emerging use in aptamer-based sensing systems. This review outlines the status of OTA contamination and conventional detection methods for OTA. Various G4-based methods to detect OTA developed in recent years are summarized along with their advantages and disadvantages compared to existing approaches.</p>