AUTHOR=Tan Yushi , Wang Jiabo , Zhang Hong-Yu , Zhang Yuecheng , Zhao Jiquan 

TITLE=The C3-H Bond Functionalization of Quinoxalin-2(1H)-Ones With Hypervalent Iodine(III) Reagents

JOURNAL=Frontiers in Chemistry

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2020.00582

DOI=10.3389/fchem.2020.00582

ISSN=2296-2646

ABSTRACT=<p>The modification of quinoxalin-2(1<italic>H</italic>)-ones <italic>via</italic> direct C-H bond functionalization has begun to receive widespread attention, due to quinoxalin-2(1<italic>H</italic>)-one derivatives' various biological activities and pharmaceutical properties. This mini review concentrates on the accomplishments of arylation, trifluoromethylation, alkylation, and alkoxylation of quinoxalin-2(1<italic>H</italic>)-ones with hypervalent iodine(III) reagents as reaction partners or oxidants. The reaction conditions and mechanisms are compared and discussed in detail.</p>