AUTHOR=Wu Ye , Huang Rui , Jin Jin-Mei , Zhang Li-Jun , Zhang Hong , Chen Hong-Zhuan , Chen Li-Li , Luan Xin 

TITLE=Advances in the Study of Structural Modification and Biological Activities of Anoplin

JOURNAL=Frontiers in Chemistry

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2020.00519

DOI=10.3389/fchem.2020.00519

ISSN=2296-2646

ABSTRACT=<p>Anoplin is an amphipathic, α-helical bioactive peptide from wasp venom. In recent years, pharmaceutical and organic chemists discovered that anoplin and its derivatives showed multiple pharmacological activities in antibacterial, antitumor, antifungal, and antimalarial activities. Owing to the simple and unique structure and diverse biological activities, anoplin has attracted considerable research interests. This review highlights the advances in structural modification, biological activities, and the outlook of anoplin in order to provide a basis for new drug design and delivery.</p>