AUTHOR=Listro Roberta , Stotani Silvia , Rossino Giacomo , Rui Marta , Malacrida Alessio , Cavaletti Guido , Cortesi Michela , Arienti Chiara , Tesei Anna , Rossi Daniela , Giacomo Marcello Di , Miloso Mariarosaria , Collina Simona TITLE=Exploring the RC-106 Chemical Space: Design and Synthesis of Novel (E)-1-(3-Arylbut-2-en-1-yl)-4-(Substituted) Piperazine Derivatives as Potential Anticancer Agents JOURNAL=Frontiers in Chemistry VOLUME=8 YEAR=2020 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2020.00495 DOI=10.3389/fchem.2020.00495 ISSN=2296-2646 ABSTRACT=
Despite the fact that significant advances in treatment of common cancers have been achieved over the years, orphan tumors still represent an important unmet medical need. Due to their complex multifactorial origin and limited number of cases, such pathologies often have very limited treatment options and poor prognosis. In the search for new anticancer agents, our group recently identified