AUTHOR=Li Weiwei , Zhang Jun , He Jing , Xu Liang , Vaccaro Luigi , Liu Ping , Gu Yanlong 

TITLE=I2/DMSO-Catalyzed Transformation of N-tosylhydrazones to 1,2,3-thiadiazoles

JOURNAL=Frontiers in Chemistry

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2020.00466

DOI=10.3389/fchem.2020.00466

ISSN=2296-2646

ABSTRACT=<p>An iodine/DMSO catalyzed selective cyclization of <italic>N</italic>-tosylhydrazones with sulfur without adding external oxidant was developed for the synthesis of 4-aryl-1,2,3-thiadiazoles. In this reaction, oxidation of HI by using DMSO as dual oxidant and solvent is the key, which allowed the regeneration of I<sub>2</sub>, ensuring thus the success of the synthesis. This protocol features by simple operation, high step-economy (one-pot fashion), broad substrate scope as well as scale-up ability.</p>