AUTHOR=Chen Yang , Xiao Shu , Huang Jian , Xue Wei , He Shuzhong 

TITLE=A Synthetic View on Haedoxans and Related Neolignans From Phryma leptostachya

JOURNAL=Frontiers in Chemistry

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2020.00460

DOI=10.3389/fchem.2020.00460

ISSN=2296-2646

ABSTRACT=<p>Haedoxans are a series of sesquilignan natural products isolated from the traditional insecticidal plant <italic>Phryma leptostachya</italic>. Given their significant insecticidal activity, haedoxans and related analogs have been considered as potential agents for plant defense. Moreover, these compounds also exhibit promising antifungal, antibacterial, and anticancer activities. The present paper is a review of the structure, biological activity, and chemical synthesis of naturally occurring haedoxan-like molecules.</p>