AUTHOR=Zhao Meng , Xiao Yi , Otsuka Satoshi , Nakao Yoichi , Guo Yian , Ye Tao 

TITLE=Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues

JOURNAL=Frontiers in Chemistry

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2020.00410

DOI=10.3389/fchem.2020.00410

ISSN=2296-2646

ABSTRACT=<p>Kakeromamide A (<bold>1</bold>), the first marine cyclopeptide inducing neural stem cells differentiation into astrocytes, was synthesized in 12 longest linear steps and 14% overall yield. Using this synthetic approach, four analogs of kakeromamide A were prepared and evaluated for neural differentiation- modulating activity.</p>