AUTHOR=Guo Jiaocen , Kong Fandong , Ma Qingyun , Xie Qingyi , Zhang Renshuai , Dai Haofu , Wu Yougen , Zhao Youxing 

TITLE=Meroterpenoids With Protein Tyrosine Phosphatase 1B Inhibitory Activities From the Fruiting Bodies of Ganoderma ahmadii

JOURNAL=Frontiers in Chemistry

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2020.00279

DOI=10.3389/fchem.2020.00279

ISSN=2296-2646

ABSTRACT=<p><italic>Ganoderma</italic> fungi have long been used as functional foods and traditional medicines in Asian countries. <italic>Ganoderma ahmadii</italic> is one of the main species of <italic>Ganoderma</italic> fungi distributed in Hainan province of China, the fruiting bodies of which have been used in folk to lower blood sugar for a long time. A chemical investigation of the fruiting bodies of <italic>Ganoderma ahmadii</italic> led to the isolation of seven new meroterpenoids, named ganoduriporols F-L <bold>(1–7)</bold>. The chemical structures of the compounds were elucidated by spectroscopic data including HRESIMS and 2D NMR. Compounds <bold>5–7</bold> represent the first examples of ganoduriporol-type meroterpenoids bearing oxepane rings in their skeletons. Compounds <bold>1–4</bold> showed inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) comparable to the positive control Na<sub>3</sub>VO<sub>4</sub>, with IC<sub>50</sub> values of 17, 20, 19, and 23 μM, respectively.</p>