Li Fu
Aimin Yu- 1College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou, China
- 2Department of Chemistry and Biotechnology, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn, VIC, Australia
Editorial on the Research Topic
Polydopamine-Based Nanostructures: Synthesis and Biomedical Applications
Polydopamine (PDA) is a brown-black insoluble biopolymer with a melanin structure. Inspired by the powerful adhesion of invertebrate mussels, PDA came to public attention as a new coating material in 2007. One of the advantages of PDA coating is its mild and simple process which is based on the in-situ polymerization of its monomer dopamine (DA). It has been demonstrated that PDA can not only form uniform coatings on various organic and inorganic substrates including superhydrophobic surfaces, but also allow for further functionalization and secondary reactions. Due to its excellent biocompatibility and low cytotoxicity, PDA and its composite nanostructures have found many applications in various biomedical fields. This Research Topic collects a diverse range of fundamentals and applications of PDA, including nanomaterial synthesis, enzyme encapsulation, electrochemical sensing and antifungal agents.
The Research Topic contains two review articles. Xiong et al. summarized the application of PDA in photosensitizer. This is an important emerging area particularly for photodynamic therapy field. PDA-based materials are leveraged to overcome many most crucial shortcomings of current photosensitizer such as low light stability, rapid blood clearance and poor water solubility. The second review article wrote by Talon et al. focused on the use of PDA to improve host responses to polytetrafluoroethylene-based implants, specifically for the treatment of the Congenital Diaphragmatic Hernia. The PDA coating on the polytetrafluoroethylene surface showed incredible performance for cell attachment. Based on the in vitro evaluation, in vivo experiments in rats were recommended by authors to further confirm the results.
The three original research articles are showcases of three specific applications of DPA. The first work by Tran et al. reports the preparation of PDA hollow capsules by coating silica particles with PDA followed by dissolving silica template simply in water. Biomacromolecules such as catalase could be encapsulated into PDA hollow capsules with remained bio-functionality. This work provides an eco-friendly approach for hollow capsule fabrication which could be utilized as a drug delivery system. In the second work, Alves et al. investigated the antifungal performance of the polydimethylsiloxane after the surface modification of liposomal amphotericin embedded PDA. This work shows the liposomal amphotericin embedded PDA coating has an ability to prevent the attachment of Candida albicans and kill the adherent cells, without having toxic effect toward mammalian cells. The third work conducted by Fu et al. investigated the use of the PDA-functionalized graphene for the extraction of plant essential compounds for the electrochemical medical plant identification. The plant tissue wrapped by PDA-functionalized graphene has a very good film-forming property. Additionally, the PDA-functionalized graphene could adsorb and concentrate bioactive components from plant tissue and subsequently enhance the electrochemical signals.
The contributions in this Research Topic of Polydopamine-Based Nanostructures: Synthesis and Biomedical Applications highlight that manipulating PDA for surface modification enables to reach toward utilization. The applications covered in this Research Topic, supported by the state-of-the-art analysis and characterization, provide a dissection of the status of the field of the PDA-based biomedical applications. The in vivo study of the use of the PDA is worthy of exploring in the near future.
Author Contributions
All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication.
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Acknowledgments
We would like to thank all the authors and reviewers for their dedication and time in this Frontiers Research Topic.
Keywords: nanostructures, polydopamine, biomedical application, photosensitizer, host response diagnostics, drug delivery
Citation: Fu L and Yu A (2020) Editorial: Polydopamine-Based Nanostructures: Synthesis and Biomedical Applications. Front. Chem. 8:206. doi: 10.3389/fchem.2020.00206
Received: 20 February 2020; Accepted: 04 March 2020;
Published: 20 March 2020.
Edited and reviewed by: Pellegrino Musto, Italian National Research Council, Italy
Copyright © 2020 Fu and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Li Fu, fuli@hdu.edu.cn; Aimin Yu, aiminyu@swin.edu.au