AUTHOR=Ríos-Lombardía Nicolás , Rodríguez-Álvarez María Jesús , Morís Francisco , Kourist Robert , Comino Natalia , López-Gallego Fernando , González-Sabín Javier , García-Álvarez Joaquín 

TITLE=DESign of Sustainable One-Pot Chemoenzymatic Organic Transformations in Deep Eutectic Solvents for the Synthesis of 1,2-Disubstituted Aromatic Olefins

JOURNAL=Frontiers in Chemistry

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2020.00139

DOI=10.3389/fchem.2020.00139

ISSN=2296-2646

ABSTRACT=<p>The self-assembly of styrene-type olefins into the corresponding stilbenes was conveniently performed in the <italic>Deep Eutectic Solvent</italic> (<italic>DES</italic>) mixture 1<italic>ChCl</italic>/2<italic>Gly</italic> under air and in the absence of hazardous organic co-solvents using a one-pot chemo-biocatalytic route. Here, an enzymatic decarboxylation of <italic>p</italic>-hydroxycinnamic acids sequentially followed by a ruthenium-catalyzed metathesis of olefins has been investigated in <italic>DES</italic>. Moreover, and to extend the design of chemoenzymatic processes in <italic>DESs</italic>, we also coupled the aforementioned enzymatic decarboxylation reaction to now concomitant Pd-catalyzed Heck-type C-C coupling to produce biaryl derivatives under environmentally friendly reaction conditions.</p>