AUTHOR=Wang Rongchen , Gao Wei , Gao Jie , Xu Ge , Zhu Tianli , Gu Xianfeng , Zhao Chunchang 

TITLE=A Förster Resonance Energy Transfer Switchable Fluorescent Probe With H2S-Activated Second Near-Infrared Emission for Bioimaging

JOURNAL=Frontiers in Chemistry

VOLUME=7

YEAR=2019

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2019.00778

DOI=10.3389/fchem.2019.00778

ISSN=2296-2646

ABSTRACT=<p>Real-time and accurate detection of endogenous hydrogen sulfide is of great biomedical significance. Here, a FRET-based fluorescent probe for ratiometric detection of H<sub>2</sub>S was designed to comprise an AIE luminophore TPE as an energy donor and a monochlorinated BODIPY dye as an energy acceptor and H<sub>2</sub>S-responsive site. Such a designed probe showed H<sub>2</sub>S-dependent ratiometric and light-up NIR-II emission, enabling accurate imaging of H<sub>2</sub>S-rich cancer cells and identification of H<sub>2</sub>S-rich tumors with high resolution.</p>