AUTHOR=Pages Benjamin J. , Gurung Sarah P. , McQuaid Kane , Hall James P. , Cardin Christine J. , Brazier John A. TITLE=Stabilization of Long-Looped i-Motif DNA by Polypyridyl Ruthenium Complexes JOURNAL=Frontiers in Chemistry VOLUME=7 YEAR=2019 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2019.00744 DOI=10.3389/fchem.2019.00744 ISSN=2296-2646 ABSTRACT=

A spectroscopic study of the interactions of Λ- and Δ-[Ru(phen)2(dppz)]2+ with i-motif DNA containing thymine loops of various lengths. In the presence of i-motifs, the luminescence of the Λ enantiomer was enhanced much more than the Δ. Despite this, the effect of each enantiomer on i-motif thermal stability was comparable. The sequences most affected by [Ru(phen)2(dppz)]2+ were those with long thymine loops; this suggests that long-looped i-motifs are attractive targets for potential transition metal complex drugs and should be explored further in drug design.