AUTHOR=Xie Chun-Lan , Xia Jin-Mei , Lin Ting , Lin Ying-Jie , Lin Yu-Kun , Xia Man-Li , Chen Hai-Feng , Luo Zhu-Hua , Shao Zong-Ze , Yang Xian-Wen 

TITLE=Andrastone A From the Deep-Sea-Derived Fungus Penicillium allii-sativi Acts as an Inducer of Caspase and RXRα-Dependent Apoptosis

JOURNAL=Frontiers in Chemistry

VOLUME=7

YEAR=2019

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2019.00692

DOI=10.3389/fchem.2019.00692

ISSN=2296-2646

ABSTRACT=<p>Two new (<bold>1</bold>, <bold>2</bold>) and one known (<bold>3</bold>) meroterpenoids were isolated from the deep-sea-derived fungus <italic>Penicillium allii-sativi</italic>. The relative structures of new compounds were determined on the basis of an extensive analysis of the NMR and MS data, and the absolute configurations were established by ECD calculations. Andrastone A (<bold>1</bold>) is a rare andrastin bearing an unusual cyclopentan-1,3-dione. It shows a selectively antiproliferative effect against HepG2 tumor cells with an IC<sub>50</sub> value of 7.8 μM. Mechanism study showed that apoptosis via Caspase and RXRα pathways are responsible for the inhibitory effect.</p>