AUTHOR=Klochkov Sergey G. , Pukhov Sergey A. , Afanasieva Svetlana V. , Neganova Margarita E. , Ananiev Ivan V. , Avila-Rodriguez Marco , Tarasov Vadim V. , Aliev Gjumrakch 

TITLE=A Novel Heterocyclic System Based on Natural Epoxyalantolactone

JOURNAL=Frontiers in Chemistry

VOLUME=7

YEAR=2019

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2019.00655

DOI=10.3389/fchem.2019.00655

ISSN=2296-2646

ABSTRACT=<p>Natural sesquiterpene lactones which contain an exocyclic methylene group in the β-position of the lactone ring react readily with N-nucleophiles. When studying the reaction of the natural epoxyalantolactone with the primary amines we demonstrate the formation of a new heterocyclic system—the hydrogenated benzo[g]furo[4,3,2-cd]indol-3(1H)-one. Spectral data on the characteristics of the synthesized compounds are presented. The data on the reaction mechanisms and its applicability for the preparation are discussed.</p>