AUTHOR=Shaabani Shabnam , Shaabani Ahmad , Kucerakova Monika , Dusek Michal 

TITLE=A One-Pot Synthesis of Oxazepine-Quinazolinone bis-Heterocyclic Scaffolds via Isocyanide-Based Three-Component Reactions

JOURNAL=Frontiers in Chemistry

VOLUME=7

YEAR=2019

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2019.00623

DOI=10.3389/fchem.2019.00623

ISSN=2296-2646

ABSTRACT=<p>A novel, efficient and environmentally friendly approach has been developed for the synthesis of biologically important <italic>bis</italic>-heterocyclic oxazepine-quinazolinone derivatives. The structurally interesting compounds of high purity were synthesized by a one-pot three-component reaction of 2-(2-formylphenoxy) acetic acid and 2-aminobenzamide as bifunctional reagents and an isocyanide without using any catalyst, with excellent overall yields.</p>