AUTHOR=Ostacolo Carmine , Di Sarno Veronica , Musella Simona , Ciaglia Tania , Vestuto Vincenzo , Pepe Giacomo , Merciai Fabrizio , Campiglia Pietro , Gomez Monterrey Isabel M. , Bertamino Alessia 

TITLE=An Efficient Approach to Aromatic Aminomethylation Using Dichloromethane as Methylene Source

JOURNAL=Frontiers in Chemistry

VOLUME=7

YEAR=2019

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2019.00568

DOI=10.3389/fchem.2019.00568

ISSN=2296-2646

ABSTRACT=<p>Ultrasound-promoted N-aminomethylation of indoles can be achieved in basic medium using sodium hydride and dichloromethane (DCM) as C1 donor source. This innovative amino methylation protocol results in good to excellent yields of multifunctional indole derivatives. The procedure is also applicable to other aza-heterocyclic compounds and, interestingly, affords direct access to aminomethyl-substituted aryl alcohols.</p>