AUTHOR=Li Lei , Tian Feng , Chang Hao , Zhang Jie , Wang Cheng , Rao Wei , Hu Huan TITLE=Interactions of Bacteria With Monolithic Lateral Silicon Nanospikes Inside a Microfluidic Channel JOURNAL=Frontiers in Chemistry VOLUME=7 YEAR=2019 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2019.00483 DOI=10.3389/fchem.2019.00483 ISSN=2296-2646 ABSTRACT=
This paper presents a new strategy of integrating lateral silicon nanospikes using metal-assisted chemical etching (MacEtch) on the sidewall of micropillars for on-chip bacterial study. Silicon nanospikes have been reported to be able to kill bacteria without using chemicals and offer a new route to kill bacteria and can prevent the overuse of antibiotics to reduce bacteria. We demonstrated a new methodology to fabricate a chip with integrated silicon nanospikes onto the sidewalls of micropillars inside the microfluidic channel and attested its interactions with the representative gram-negative bacteria