AUTHOR=Zi Cheng-Ting , Gao Ying-Sheng , Yang Liu , Feng Shu-Yun , Huang Yue , Sun Li , Jin Yi , Xu Feng-Qing , Dong Fa-Wu , Li Yan , Ding Zhong-Tao , Zhou Jun , Jiang Zi-Hua , Yuan Sheng-Tao , Hu Jiang-Miao TITLE=Design, Synthesis, and Biological Evaluation of Novel Biotinylated Podophyllotoxin Derivatives as Potential Antitumor Agents JOURNAL=Frontiers in Chemistry VOLUME=7 YEAR=2019 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2019.00434 DOI=10.3389/fchem.2019.00434 ISSN=2296-2646 ABSTRACT=
Podophyllotoxin has long been used as an active substance for cytotoxic activity. Fourteen novel biotinylated podophyllotoxin derivatives were designed, synthesized, and evaluated for cytotoxic activity for this study. The synthesized compounds were evaluated for cytotoxic activity in the following human cancer cell lines, SW480, MCF-7, A-549, SMMC-7721, and HL-60 by MTT assay. Most of them exhibited potent cytotoxic effects and compound