AUTHOR=Golantsov Nikita E. , Nguyen Hung M. , Golubenkova Alexandra S. , Varlamov Alexey V. , Van der Eycken Erik V. , Voskressensky Leonid G. 

TITLE=Three-Component Reaction of 3-Arylidene-3H-Indolium Salts, Isocyanides, and Alcohols

JOURNAL=Frontiers in Chemistry

VOLUME=7

YEAR=2019

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2019.00345

DOI=10.3389/fchem.2019.00345

ISSN=2296-2646

ABSTRACT=<p>A novel isocyanide-based multicomponent synthesis of alkyl aryl(indol-3-yl)acetimidates has been established. Starting from aryl(indol-3-yl)methylium tetrafluoroborates, aromatic isocyanides and alcohols, the imidates were obtained in moderate to very good yields. Consecutive four-component synthesis of the above mentioned imidates from N-alkylindoles, aromatic aldehydes, aromatic isocyanides and alcohols was also proposed. In addition, it was shown that in the presence of water, aryl(indol-3-yl)methylium tetrafluoroborates reacted with isocyanides to furnish aryl(indol-3-yl)acetamides.</p>