AUTHOR=Zidan Alaa , El-Naggar Abeer M. , Abd El-Sattar Nour E. A. , Ali Ali Khalil , El Kaïm Laurent 

TITLE=Raising the Diversity of Ugi Reactions Through Selective Alkylations and Allylations of Ugi Adducts

JOURNAL=Frontiers in Chemistry

VOLUME=7

YEAR=2019

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2019.00020

DOI=10.3389/fchem.2019.00020

ISSN=2296-2646

ABSTRACT=<p>We report here selective Tsuji-Trost type allylation of Ugi adducts using a strategy based on the enhanced nucleophilicity of amide dianions. Ugi adducts derived from aromatic aldehydes were easily allylated at their peptidyl position with allyl acetate in the presence of palladium catalysts. These substitutions were compared to more classical transition metal free allylations using allyl bromides.</p>