AUTHOR=Pöthig Alexander , Ahmed Sara , Winther-Larsen Hanne Cecilie , Guan Shengyang , Altmann Philipp J. , Kudermann Jürgen , Santos Andresen Adriana Magalhães , Gjøen Tor , Høgmoen Åstrand Ove Alexander 

TITLE=Antimicrobial Activity and Cytotoxicity of Ag(I) and Au(I) Pillarplexes

JOURNAL=Frontiers in Chemistry

VOLUME=6

YEAR=2018

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2018.00584

DOI=10.3389/fchem.2018.00584

ISSN=2296-2646

ABSTRACT=<p>The biological activity of four pillarplex compounds featuring different metals and anions was investigated. The toxicity of the compounds against four bacterial strains [<italic>Bacillus subtilis</italic> (ATCC6633), <italic>Staphylococcus aureus</italic> (ATCC6538), <italic>Escherichia coli</italic> (UVI isolate), <italic>Pseudomonas aeruginosa</italic>], one fungus (<italic>Candida albicans</italic>), and a human cell line (HepG2) was determined. Additionally, a UV-Vis titration study of the pillarplexes was carried out to check for stability depending on pH- and chloride concentration changes and evaluate the applicability in physiological media. All compounds are bioactive: the silver compounds showed higher activity against bacteria and fungi, and the corresponding gold pillarplexes were less toxic against human cells.</p>