AUTHOR=Tian Yongqi , Lin Xiuping , Zhou Xuefeng , Liu Yonghong 

TITLE=Phenol Derivatives From the Sponge-Derived Fungus Didymellaceae sp. SCSIO F46

JOURNAL=Frontiers in Chemistry

VOLUME=6

YEAR=2018

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2018.00536

DOI=10.3389/fchem.2018.00536

ISSN=2296-2646

ABSTRACT=<p>Seven new phenol derivatives named coleophomones E and F (<bold>1</bold>, <bold>2</bold>), diorcinols L and M (<bold>3</bold>, <bold>4</bold>), 1-hydroxy-6-methyl-11-methoxy-8-hydroxymethylxanthone (<bold>5</bold>), porric acid E (<bold>6</bold>), and 7-(2-hydroxyphenyl) butane-7,8,9-triol (<bold>7</bold>), were isolated from the EtOAc extract of the marine sponge-derived fungus <italic>Didymellaceae</italic> sp. SCSIO F46, together with 10 known compounds. Their structures were determined by spectroscopic analyses, including NMR, MS, X-ray diffraction, and theoretical calculations. Each of <bold>1</bold> and <bold>2</bold> contains an unusual spiro [cyclohexane-1,2′-inden] moiety, which is relatively seldom in nature products. Cytotoxic and COX-2 inhibitory activities of all purified compounds were tested and evaluated. Compound <bold>3</bold> displayed obvious cytotoxicities against Huh-7, HeLa, DU145 and HL60 cells (IC<sub>50</sub> values 5.7–9.6 μM) and weak activities against other five cell lines, while <bold>8</bold> showed weak cytotoxicities against HeLa and HL7702 cells. Compound <bold>6</bold> displayed COX-2 inhibitory activity with IC<sub>50</sub> value of 3.3 μM.</p>