AUTHOR=Mouterde Louis M. M. , Allais Florent 

TITLE=Microwave-Assisted Knoevenagel-Doebner Reaction: An Efficient Method for Naturally Occurring Phenolic Acids Synthesis

JOURNAL=Frontiers in Chemistry

VOLUME=6

YEAR=2018

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2018.00426

DOI=10.3389/fchem.2018.00426

ISSN=2296-2646

ABSTRACT=<p>The common chemical method to synthesize Phenolic Acids (PAs) involves a relatively considerable energy intake. In order to solve this issue, microwave-assisted Knoevenagel-Doebner condensations were developed. Nevertheless, these synthetic procedures prove difficult to reproduce. Herein, we developed and optimized—by using a combination of a Design of Experiment and a standard optimization approach—a reliable procedure that converts naturally occuring <italic>p</italic>-hydroxybenzaldehydes into the corresponding PAs with conversions of 86–99% and in 85–97% yields.</p>