AUTHOR=Mioc Marius , Avram Sorin , Bercean Vasile , Kurunczi Ludovic , Ghiulai Roxana M. , Oprean Camelia , Coricovac Dorina E. , Dehelean Cristina , Mioc Alexandra , Balan-Porcarasu Mihaela , Tatu Calin , Soica Codruta TITLE=Design, Synthesis and Biological Activity Evaluation of S-Substituted 1H-5-Mercapto-1,2,4-Triazole Derivatives as Antiproliferative Agents in Colorectal Cancer JOURNAL=Frontiers in Chemistry VOLUME=6 YEAR=2018 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2018.00373 DOI=10.3389/fchem.2018.00373 ISSN=2296-2646 ABSTRACT=
Colon cancer is a widespread pathology with complex biochemical etiology based on a significant number of intracellular signaling pathways that play important roles in carcinogenesis, tumor proliferation and metastasis. These pathways function due to the action of key enzymes that can be used as targets for new anticancer drug development. Herein we report the synthesis and biological antiproliferative evaluation of a series of novel S-substituted 1