AUTHOR=Wang Liping , Han Xiuli , Zhu Guoliang , Wang Yi , Chairoungdua Arthit , Piyachaturawat Pawinee , Zhu Weiming 

TITLE=Polyketides From the Endophytic Fungus Cladosporium sp. Isolated From the Mangrove Plant Excoecaria agallocha

JOURNAL=Frontiers in Chemistry

VOLUME=6

YEAR=2018

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2018.00344

DOI=10.3389/fchem.2018.00344

ISSN=2296-2646

ABSTRACT=<p>Five new polyketides (<bold>2</bold>–<bold>6</bold>) and ten known compounds (<bold>1</bold> and <bold>7</bold>–<bold>15</bold>) were obtained from the fermentation products of the endophytic fungus <italic>Cladosporium</italic> sp. OUCMDZ-302 with the mangrove plant, <italic>Excoecaria agallocha</italic> (Euphorbiaceae). The new structures of <bold>2</bold>–<bold>6</bold> were established on the basis of ECD, specific rotation and spectroscopic data as well as the chemical calculation. Compound <bold>7</bold> showed cytotoxicity against H1975 cell line with an IC<sub>50</sub> value of 10.0 μM. Compounds <bold>4</bold> and <bold>8</bold>–<bold>10</bold> showed radical scavenging activity against DPPH with the IC<sub>50</sub> values of 2.65, 0.24, 5.66, and 6.67 μM, respectively. In addition, the absolute configuration of compound <bold>1</bold> was solidly determined by X-ray and sugar analysis of the acidic hydrolysates for the first time as well as those of compounds <bold>8</bold>–<bold>10</bold> in this paper.</p>