AUTHOR=Gumerova Nadiia I. , Al-Sayed Emir , Krivosudský Lukáš , Čipčić-Paljetak Hana , Verbanac Donatella , Rompel Annette TITLE=Antibacterial Activity of Polyoxometalates Against Moraxella catarrhalis JOURNAL=Frontiers in Chemistry VOLUME=6 YEAR=2018 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2018.00336 DOI=10.3389/fchem.2018.00336 ISSN=2296-2646 ABSTRACT=

The antibacterial activity of 29 different polyoxometalates (POMs) against Moraxella catarrhalis was investigated by determination of the minimum inhibitory concentration (MIC). The Preyssler type polyoxotungstate (POT) [NaP₅W₃₀O₁₁₀]¹⁴⁻ demonstrates the highest activity against M. catarrhalis (MIC = 1 μg/ml) among all tested POMs. Moreover, we show that the Dawson type based anions, [P₂W₁₈O₆₂]⁶⁻, [(P₂O₇)Mo₁₈O₅₄]⁴⁻, [As₂Mo₁₈O₆₂]⁶⁻, [H₃P₂W₁₅V₃O₆₂]⁶⁻, and [AsW₁₈O₆₀]⁷⁻ are selective on M. catarrhalis (MIC range of 2-8 μg/ml). Among the six tested Keggin type based POTs ([PW₁₂O₄₀]³⁻, [H₂PCoW₁₁O₄₀]⁵⁻, [H₂CoTiW₁₁O₄₀]⁶⁻, [SiW₁₀O₃₆]⁸⁻, [SbW₉O₃₃]⁹⁻, [AsW₉O₃₃]⁹⁻), only the mono-substituted [H₂CoTiW₁₁O₄₀]⁶⁻ showed MIC value comparable to those of the Dawson type group. Polyoxovanadates (POVs) and Anderson type POMs were inactive against M. catarrhalis within the tested concentration range (1-256 μg/ml). Four Dawson type POMs [P₂W₁₈O₆₂]⁶⁻, [(P₂O₇)Mo₁₈O₅₄]⁴⁻, [As₂Mo₁₈O₆₂]⁶⁻, [H₃P₂W₁₅V₃O₆₂]⁶⁻ and the Preyssler POT [NaP₅W₃₀O₁₁₀]¹⁴⁻ showed promising antibacterial activity against M. catarrhalis (MICs < 8 μg/ml) and were therefore tested against three additional bacteria, namely S. aureus, E. faecalis, and E. coli. The most potent antibacterial agent was [NaP₅W₃₀O₁₁₀]¹⁴⁻, exhibiting the lowest MIC values of 16 μg/ml against S. aureus and 8 μg/ml against E. faecalis. The three most active compounds ([NaP₅W₃₀O₁₁₀]¹⁴⁻, [P₂W₁₈O₆₂]⁶⁻, and [H₃P₂W₁₅V₃O₆₂]⁶⁻) show bacteriostatic effects in killing kinetics study against M. catarrhalis. We demonstrate, that POM activity is mainly depending on composition, shape, and size, but in the case of medium-size POTs (charge is more than −12 and number of addenda atoms is not being higher than 22) its activity correlates with the total net charge.