AUTHOR=Bermudez Adriana , Alba Martha P. , Vanegas Magnolia , Patarroyo Manuel A. , Patarroyo Manuel E. 

TITLE=Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1* PBRs in Fully-Protective Malaria Vaccine Components

JOURNAL=Frontiers in Chemistry

VOLUME=6

YEAR=2018

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2018.00106

DOI=10.3389/fchem.2018.00106

ISSN=2296-2646

ABSTRACT=<p>The 3D structural analysis of 62 peptides derived from highly pathogenic <italic>Plasmodium falciparum</italic> malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ<sup>*</sup> allele family) and modified <bold>i</bold>mmune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity.</p>