AUTHOR=Cho Mi Hyeon , Choi Eun-Seok , Kim Sehee , Goh Sung-Ho , Choi Yongdoo 

TITLE=Redox-Responsive Manganese Dioxide Nanoparticles for Enhanced MR Imaging and Radiotherapy of Lung Cancer

JOURNAL=Frontiers in Chemistry

VOLUME=5

YEAR=2017

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2017.00109

DOI=10.3389/fchem.2017.00109

ISSN=2296-2646

ABSTRACT=<p>In this study, we synthesized manganese dioxide nanoparticles (MnO<sub>2</sub> NPs) stabilized with biocompatible polymers (polyvinylpyrrolidone and polyacrylic acid) and analyzed their effect on non-small cell lung cancer (NSCLC) cells with or without gefitinib resistance <italic>in vitro</italic>. MnO<sub>2</sub> NPs showed glutathione (GSH)-responsive dissolution and subsequent enhancement in magnetic resonance (MR) imaging. Of note, treatment with MnO<sub>2</sub> NPs induced significant cytotoxic effects on NSCLC cells, and additional dose-dependent therapeutic effects were obtained upon X-ray irradiation. Normal cells treated with MnO<sub>2</sub> NPs were viable at the tested concentrations. In addition, increased therapeutic efficacy could be achieved when the cells were treated with MnO<sub>2</sub> NPs in hypoxic conditions. Therefore, we conclude that the use of MnO<sub>2</sub> NPs in MR imaging and combination radiotherapy may be an efficient strategy for the imaging and therapy of NSCLC.</p>