AUTHOR=Capobianco Amedeo , Caruso Tonino , Fusco Sandra , Terzidis Michael A. , Masi Annalisa , Chatgilialoglu Chryssostomos , Peluso Andrea 

TITLE=The association constant of 5′,8-cyclo-2′-deoxyguanosine with cytidine

JOURNAL=Frontiers in Chemistry

VOLUME=3

YEAR=2015

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2015.00022

DOI=10.3389/fchem.2015.00022

ISSN=2296-2646

ABSTRACT=<p>The association of 5′,8-cyclo-2′-deoxyguanosine (cdG), a DNA tandem lesion, with its complementary base cytosine has been studied by voltammetry and NMR in chloroform, using properly silylated derivatives of the two nucleobases for increasing their solubilities. Both voltammetric data and NMR titrations indicated that the Watson-Crick complex of cytidine with cdG is weaker than that with guanosine, the difference being approximately of one order of magnitude between the two association constants.</p>