AUTHOR=Dimopoulou Athina , Manta Stella , Parmenopoulou Vanessa , Kollatos Nikolaos , Christidou Ourania , Triantakonstanti Virginia V. , Schols Dominique , Komiotis Dimitri 

TITLE=An easy microwave-assisted synthesis of C8-alkynyl adenine pyranonucleosides as novel cytotoxic antitumor agents

JOURNAL=Frontiers in Chemistry

VOLUME=3

YEAR=2015

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2015.00021

DOI=10.3389/fchem.2015.00021

ISSN=2296-2646

ABSTRACT=<p>We describe the synthesis of <italic>C</italic>8-alkynyl adenine pyranonucleosides <bold>4, 5</bold>, and 8-phenylethynyl-adenine <bold>(II)</bold>, <italic>via</italic> Sonogashira cross-coupling reaction under microwave irradiation. Compounds <bold>4e</bold> and <bold>II</bold> were less cytostatic than 5-fluorouracil (almost an order of magnitude) against murine leukemia (L1210) and human cervix carcinoma (HeLa) cells, while the same compounds proved to be more active than 5-fluorouracil against human lymphocyte (CEM) cells.</p>