AUTHOR=Ashikari Yosuke , Guan Kaiteng , Nagaki Aiichiro 

TITLE=Flash functional group-tolerant biaryl-synthesis based on integration of lithiation, zincation and negishi coupling in flow

JOURNAL=Frontiers in Chemical Engineering

VOLUME=4

YEAR=2022

URL=https://www.frontiersin.org/journals/chemical-engineering/articles/10.3389/fceng.2022.964767

DOI=10.3389/fceng.2022.964767

ISSN=2673-2718

ABSTRACT=<p>We achieved an integration of a lithiation of aryl bromides, a zincation of thus-generated aryllithiums, and a Negishi coupling of the arylzinc with an aryl halide in one flow. Taking advantages of flow microreactors, biaryls bearing a wide range of functional groups, especially biaryls bearing multiple electrophilic-functionalities were synthesized.</p>