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MINI REVIEW article

Front. Chem. Biol.
Sec. Molecular Sciences
Volume 4 - 2025 | doi: 10.3389/fchbi.2025.1549003
This article is part of the Research Topic STING Signaling in Cancer Immunotherapy View all 4 articles

Multifaceted Roles of STING in Tumors: From Molecular Mechanisms to Therapeutic Strategies

Provisionally accepted
Rui Wang Rui Wang 1*Aashiq Hussain Aashiq Hussain 2
  • 1 Suqian People's Hospital of Nanjing Drum Tower Hospital Group, Suqian, China
  • 2 National University of Singapore, Singapore, Singapore

The final, formatted version of the article will be published soon.

    Since the discovery of Stimulator of Interferon Genes (STING) as a key element in recognizing cytosolic DNA and initiating interferon (IFN) production, substantial research has been conducted to comprehend the precise molecular process of its activation for the treatment of tumor and immune-related diseases. However, new research has enhanced our understanding of STING biology and shown additional major functions of STING that go beyond its capacity to stimulate (Interferon-Stimulated Genes)(ISGs). This mini-review article highlights important details of the established STING biology, including TBK1-IRF3 activation, the NF-κB and MAPK pathway, endoplasmic reticulum (ER) stress and autophagy, and lysosomeinduced degradation. We also provide an overview of the independent functions of cGAS and STING, unresolved questions that need to be addressed, and directions for future research.

    Keywords: CGAS, STING, Immune checkpoint inhibitors (ICI), Tumor Microenvironment, immune therapy

    Received: 20 Dec 2024; Accepted: 04 Feb 2025.

    Copyright: © 2025 Wang and Hussain. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Rui Wang, Suqian People's Hospital of Nanjing Drum Tower Hospital Group, Suqian, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.