AUTHOR=Richards Nigel G. J. , Naismith James H. 

TITLE=The chemistry of Formycin biosynthesis

JOURNAL=Frontiers in Chemical Biology

VOLUME=3

YEAR=2024

URL=https://www.frontiersin.org/journals/chemical-biology/articles/10.3389/fchbi.2024.1428646

DOI=10.3389/fchbi.2024.1428646

ISSN=2813-530X

ABSTRACT=<p>Remarkable progress has been made to elucidate the structural and mechanistic enzymology of the biosynthetic pathways that give rise to naturally occurring C-nucleosides. These compounds are generally cytotoxic and exhibit interesting antiviral, antibiotic and anti-parasitic activity. Here we review current knowledge concerning formycin biosynthesis and highlight deficiencies in our understanding of key chemical transformations in the pathway.</p>