AUTHOR=KozieĊ‚ Sandra , Wojtala Daria , Szmitka Magdalena , Sawka Jacek , Komarnicka Urszula K. TITLE=Can Mn coordination compounds be good candidates for medical applications? JOURNAL=Frontiers in Chemical Biology VOLUME=3 YEAR=2024 URL=https://www.frontiersin.org/journals/chemical-biology/articles/10.3389/fchbi.2024.1337372 DOI=10.3389/fchbi.2024.1337372 ISSN=2813-530X ABSTRACT=

Metal centres provide unique foci for varied biological modes of action that often but not exclusively involve redox or metal-ligand reactions. Metal complexes offer alternative and flexible coordination geometries, electron and proton transfer sites, inner and outer sphere reactivities, sites for redox-active, hemi-labile, and non-innocent ligands, and a variety of potentially controllable properties for exploitation in a therapeutic or biological context. The discovery of the first anticancer, the metal-based compound cisplatin in 1965 by Barnett Rosenberg was a historical outstanding breakthrough and led to a new area of metal-drug discovery. Some metal-based compounds have FDA approval for clinical use, while some undergo clinical trials for various medical therapies. This mini-review focuses on recent progress on Mn-based complexes with potential anticancer, antibacterial, and antifungal activities.