94% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
BRIEF RESEARCH REPORT article
Front. Cell. Neurosci.
Sec. Cellular Neurophysiology
Volume 19 - 2025 | doi: 10.3389/fncel.2025.1588894
GABAergic synaptic components are largely preserved across human and mouse neuronal models
Provisionally accepted
Beatriz Rebollo1,2*
Astghik Abrahamyan1
Ullrich Wilhelm Thomale3
Angela M Kaindl4
Melissa A. Herman1
Christian Rosenmund1,2*- 1Institute of Neurophysiology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
- 2NeuroCure, Charité University Medicine Berlin, Berlin, Baden-Wurttemberg, Germany
- 3Pediatric Neurosurgery Division, Charité University Medicine Berlin, Berlin, Baden-Württemberg, Germany
- 4Department of Pediatric Neurology, Charité University Medicine Berlin, Berlin, Baden-Württemberg, Germany
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Synaptic transmission is essential for brain function. But which characteristics of synapse function are so crucial that they are conserved between species? In general, animal models have shaped our understanding of neuronal function, although in recent years our knowledge of human neurophysiology has vastly increased. Comparative analyses between rodent and human neurons have highlighted the similarities and differences in morpho-electrical features, but the extent to which the properties of neurotransmitter release are conserved is underexplored. In this study, we compared the intrinsic properties that determine synaptic strength in cultured GABAergic neurons from mouse and human. Our findings demonstrate that, while passive neuronal properties are different across species, synaptic properties are similar, suggesting that mechanisms of synaptic transmission are conserved between mouse and human neurons. This work provides valuable insight into the extent to which animal models reflect human synaptic components at the single cell level.
Keywords: Human neurons, GABAergic Neurons, Synaptic Transmission, autaptic culture, neurotransmitter release
Received: 06 Mar 2025; Accepted: 16 Apr 2025.
Copyright: © 2025 Rebollo, Abrahamyan, Thomale, Kaindl, Herman and Rosenmund. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Beatriz Rebollo, Institute of Neurophysiology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
Christian Rosenmund, Institute of Neurophysiology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.