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REVIEW article
Front. Cell. Neurosci.
Sec. Non-Neuronal Cells
Volume 19 - 2025 | doi: 10.3389/fncel.2025.1536096
This article is part of the Research Topic Reviews in non-neuronal cells 2024 & 2025 View all 3 articles
Ca 2+ Waves in Astrocytes: Computational Modelling and Experimental Data
Provisionally accepted- 1 National Research Council (CNR), Roma, Italy
- 2 Institute for Biomedical Research and Innovation, National Research Council, IRIB-CNR, Messina, Italy
- 3 University of Messina, Messina, Sicilia, Italy
This paper examines different computational models for Calcium wave propagation in astrocytes. Through a comparative analysis of models by Goldbeter, De Young-Keizer, Atri, Li-Rinzel and De Pittà and of experimental data, the study highlights the model contributions for the understanding of Calcium dynamics. Tracing the evolution from simple to complex models, this work emphasizes the importance of integrating experimental data in order to further refine these models. The results allow to improve our understanding of the physiological functions of astrocytes, suggesting the importance of more accurate astrocyte models.
Keywords: Model, calcium wave, Astrocytes, simulation, Experimental data
Received: 28 Nov 2024; Accepted: 06 Mar 2025.
Copyright: © 2025 Musotto, Wanderlingh and Pioggia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Rosa Musotto, National Research Council (CNR), Roma, Italy
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