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ORIGINAL RESEARCH article

Front. Cell. Neurosci.
Sec. Non-Neuronal Cells
Volume 18 - 2024 | doi: 10.3389/fncel.2024.1490607
This article is part of the Research Topic Function and Regulation of Non-Neuronal Cells in the Nervous System View all 3 articles

Global Research Trends and Prospects on Immune-Related Therapy in Ischemic Stroke: A Bibliometric Analysis

Provisionally accepted
Qi Wang Qi Wang 1Lei Yuan Lei Yuan 1Fei Wang Fei Wang 2*Fei Sun Fei Sun 2*
  • 1 Medical College, Yangzhou University, Yangzhou, Jiangsu Province, China
  • 2 The Affiliated Taizhou People's Hospital, Nanjing Medical University, Taizhou, China

The final, formatted version of the article will be published soon.

    Background: Following ischemic stroke, non-neuronal cells within the nervous system play a crucial role in maintaining neurovascular unit functions, regulating metabolic and inflammatory processes of the nervous system. Investigating the functions and regulation of these cells, particularly immune cells, deepens our understanding of the complex mechanisms of neuroinflammation and immune modulation after ischemic stroke and provides new perspectives and methods for immune-related therapy.The annual distribution, journals, authors, countries, institutions, and keywords of articles published between 2015 and 2024 were visualized and analyzed using CiteSpace and other bibliometric tools.Results: A total of 1089 relevant articles or reviews were included, demonstrating an overall upward trend; The terms "cerebral ischemia", "immune response", "brain ischemia", "cerebral inflammation", "neurovascular unit", and "immune infiltration", etc. are hot keywords in this field.In recent years, research on immune-related therapy for ischemic stroke has focused on mechanisms of occurrence, protection and repair of the blood-brain barrier (BBB) by non-neuronal cells, and regulation of immunosuppression and 1 Q.W. and L.Y. contributed equally to this work and share first authorship. inflammation. Among these, reducing BBB disruption to minimize secondary brain damage has become a hotspot. At the same time, the complex roles of immune responses have attracted attention, particularly the balance between regulatory T cells and Th17 cells in regulating neuroinflammation and promoting neurological function recovery, which is crucial to reduce secondary neuronal damage and improve prognosis, potentially establishing a pivotal frontier in this domain of investigation.

    Keywords: ：Ischemic stroke, immune-related therapy, Non-neuronal cells, immune response, Citespace, Bibliometrics

    Received: 03 Sep 2024; Accepted: 09 Oct 2024.

    Copyright: © 2024 Wang, Yuan, Wang and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Fei Wang, The Affiliated Taizhou People's Hospital, Nanjing Medical University, Taizhou, China
    Fei Sun, The Affiliated Taizhou People's Hospital, Nanjing Medical University, Taizhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.