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MINI REVIEW article

Front. Cell. Neurosci.
Sec. Cellular Neuropathology
Volume 18 - 2024 | doi: 10.3389/fncel.2024.1468187
This article is part of the Research Topic Role of Microbiota in Neurocognitive Disorders: A Developmental Origin Perspective View all 5 articles

The Gut-Eye Axis: The Retinal/Ocular Degenerative Diseases And The Emergent Therapeutic Strategies

Provisionally accepted
Sonda Kammoun Sonda Kammoun 1,2Mona Rekik Mona Rekik 1,2Aryj Dlensi Aryj Dlensi 2Samir Aloulou Samir Aloulou 1,3Walid Smaoui Walid Smaoui 1,4Sahla Sellami Sahla Sellami 1Khaled Trigui Khaled Trigui 1Rahma Gargouri Rahma Gargouri 5Imen Chaari Imen Chaari 5Hayet SELLAMI Hayet SELLAMI 5,6Dhawia Elatoui Dhawia Elatoui 5Nahed Khemakhem Nahed Khemakhem 7Ines Hadrich Ines Hadrich 7Sourour Neji Sourour Neji 6,7Balkiss Abdelmoula Balkiss Abdelmoula 1Nouha Bouayed Abdelmoula Nouha Bouayed Abdelmoula 1*
  • 1 Genomics of Signalopathies at the Service of Precision Medicine LR23ES07 FMS, University of Sfax,, Sfax, Tunisia
  • 2 Ophthalmology Department, Habib Bourguiba University Hospital, Faculty of Medicine, University of Sfax, Tunisia, Sfax, Tunisia
  • 3 Medical Carcinology Department, Mohamed Ben Sassi University Hospital of Gabes, Faculty of Medicine, University of Sfax, Sfax, Tunisia
  • 4 Urology Department, Habib Bourguiba University Hospital, Faculty of Medicine, University of Sfax, Sfax, Tunisia
  • 5 Drosophila Research Unit UR22ES03 FMS, University of Sfax, Sfax, Tunisia
  • 6 Parasitology and Mycology Department, Faculty of Medicine, University of Sfax, Sfax, Tunisia
  • 7 Fungal and Parasitic Molecular Biology Laboratory LR05ES11 FMS, University of Sfax, Sfax, Tunisia

The final, formatted version of the article will be published soon.

    The interplay between human microbiota and various physiological systems has garnered significant attention in recent years. The gut microbiota plays a critical role in maintaining physiological homeostasis and influences various aspects of human health, particularly via the gut brain axis. Since 2017, the challenging concept of the gut-retina axis has emerged thanks to a network analysis emphasizing the potential role of the gut microbiota disruption in the development of the age-related macular degeneration and further retinal damages. Many other ocular disorders have been linked to the dysbiosis of the gut microbiota, including uveitis and glaucoma. It has been shown that age related macular degeneration can be prevented or reversed using a diet that induces changes in the gut microbiota. The potential link between the gut microbiota as well as others types of microbiota such as the ocular surface microbiota and the development/progression of age related as well as inherited retinal degenerations and other degenerative eye diseases, has recently been broadened. Therefore, the pathogenesis of several eye diseases has recently been associated with a larger perception called the gut eye axis. This mini-review examines the potential mechanisms underlying the gut eye axis and suggests implications for the management of eye diseases. By understanding the modulation of the gut microbiota and its impact on eye disease, this mini-review provides insight into potential therapeutic interventions and avenues for future research.

    Keywords: Gut-eye axis, Gut Microbiota, microbiota, Degenerative eye diseases, Retinopathies

    Received: 21 Jul 2024; Accepted: 09 Sep 2024.

    Copyright: © 2024 Kammoun, Rekik, Dlensi, Aloulou, Smaoui, Sellami, Trigui, Gargouri, Chaari, SELLAMI, Elatoui, Khemakhem, Hadrich, Neji, Abdelmoula and Bouayed Abdelmoula. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Nouha Bouayed Abdelmoula, Genomics of Signalopathies at the Service of Precision Medicine LR23ES07 FMS, University of Sfax,, Sfax, Tunisia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.